Etude de phase 2b, ouverte, à un seul bras et multicentrique évaluant l'efficacité et l'innocuité de l'adavosertib dans le traitement du carcinome séreux utérin récurrent ou persistant

Essai clinique

Type : Industriel
Statut : Ouvert
Phase : II
Étape du traitement : Thérapie ciblée
Date d'ouverture : 30/11/2020
Date clôture : 30/09/2024
Promoteur : AstraZeneca
Progression du cancer: Loco-régional
Résumé :

This Phase 2b study aims to evaluate the efficacy and safety of adavosertib, an inhibitor of the tyrosine kinase WEE1, in subjects with recurrent or persistent uterine serous carcinoma (USC) who have previously received at least 1 prior platinum-based chemotherapy regimen for the management of USC.

Domaines/spécialités :
  • Cancers gynécologiques
    • Col de l’utérus
Pathologies :
  • Carcinome in situ du col de l'utérus - Cim10 : D06
Liens externes :

Critères de population

Sexe : Homme et femme
Age minimum : 18 ans
Critères d’inclusion :
  1. Subjects must be aged ≥ 18 years of age inclusive, at the time of signing the informed consent.
  2. Histologically confirmed recurrent or persistent USC. Subjects with carcinosarcomas are not eligible.
  3. Evidence of measurable disease as per RECIST v1.1.
  4. At least 1 prior platinum-based chemotherapy regimen for the management of USC. Prior receipt of immune checkpoint inhibitors, vascular endothelial growth factor (VEGF) inhibitors and human epidermal growth factor receptor 2 (HER2) targeted therapy is allowed. There is no restriction on the number of prior lines of systemic therapy.
  5. Eastern Cooperative Oncology Group performance (ECOG) status 0-1.
  6. Life expectancy ≥ 12 weeks.
  7. Subjects must have normal organ and marrow function at baseline, within 7 days prior to study drug administration.
  8. Consent to submit and provide a mandatory Formalin-fixed paraffin-embedded tumor sample for central testing.
  9. Female subjects who are not of childbearing potential and women of childbearing potential who agree to use adequate contraceptive measures.
Critères d’exclusion :
  1. Any underlying medical condition and uncontrolled intercurrent illness that would impair the ability of the subject to receive study treatment, as judged by the investigator.
  2. With the exception of alopecia, any unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 at the time of starting study treatment.
  3. Unable to swallow oral medications.
  4. Spinal cord compression or metastases unless asymptomatic, stable, and not requiring steroids for at least 4 weeks prior to start of study intervention.
  5. Subjects with current signs or symptoms of bowel obstruction, including sub-occlusive disease, related to underlying disease.

  6. Any of the following cardiac diseases currently or within the last 6 months:

    • Unstable angina pectoris
    • Acute myocardial infarction
    • Congestive heart failure
    • Conduction abnormality not controlled with pacemaker or medication
    • Significant ventricular or supraventricular arrhythmias
  7. History of Torsades de pointes unless all risk factors that contributed to Torsades have been corrected.
  8. a) Resting corrected QTc interval using the Fridericia formula (QTcF) > 480 msec, or b) congenital long QT syndrome.
  9. Immunocompromised subjects.
  10. Subjects with known active hepatitis (ie, hepatitis B or C).

  11. Prior treatment with any of the following:

    • Cell cycle checkpoint inhibitor.
    • Anticancer treatment drug ≤ 21 days (≤ 6 weeks for nitrosoureas or mitomycin C) or use of an investigational product within 5 half-lives prior to the first dose of adavosertib. For Programmed cell death-1 receptor (PD-1) /Programmed death-ligand 1 (PD-L1) inhibitors, a minimum of 28 days since last dose is required.
    • Prescription or non-prescription drugs known as moderate to strong inhibitors / inducers of CYP3A4 within 2 weeks prior to the first dose of study treatment.
    • Herbal medications 7 days prior to first dose of study treatment.
  12. Palliative radiotherapy with a limited field of radiation within 2 weeks or with wide field of radiation within 4 weeks prior to the first dose of study intervention.
  13. Major surgical procedures ≤ 28 days, or minor surgical procedures ≤ 7 days, prior to beginning study.
  14. Subjects with a known hypersensitivity or contraindication to adavosertib or any of the excipients of the product.
  15. Currently pregnant or breast-feeding.

Centre d'investigation

En cours
Nom : Centre Georges François Leclerc - CGFL
Ville : DIJON (21)
RESPONSABLE MÉDICAL
Nom : Dr BENGRINE
Prénom : Leïla
Téléphone : Non disponible
Email : lbengrine@cgfl.fr
CONTACT TECHNIQUE
Nom : LE BERRE
Prénom : Kevin
Téléphone : 03 80 73 77 51
Email : kleberre@cgfl.fr

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