Modifications de la microvascularisation rétinienne avec une thérapie anti-angiogénique ciblée dans le cancer colorectal

Essai clinique

Type : Académique
Statut : Ouvert
Phase : I
Étape du traitement : Stade métastatique 1er ligne
Date d'ouverture : 14/12/2020
Date clôture : 14/07/2024
Promoteur : Centre Georges Francois Leclerc
Progression du cancer: Loco-régional et à distance
Résumé :

Retinal microvascularization can provide important informations to systemic vascular phenomena. The non-invasive quantitative description of the retinal vascularization is now possible by performing OCT-angiography and their image analysis software (vascular density and retinal perfusion). Systemic microvacular changes during the establishment of oncological treatment by targeted antiangiogenic therapy are little described in the literature. The objective of this pilot study is to describe the evolution of the retinal vascular density of patients with antiangiogenic drugs. In addition, the evolution of the retinal vascular density of patients on antiangiogenic drugs will study as a function of the response to the treatment and the toxicity of these treatments.

Domaines/spécialités :
  • Cancers digestifs
    • Colon
    • Rectum
Pathologies :
  • Tumeur maligne du côlon - Cim10 : C18
  • Tumeur maligne du rectum - Cim10 : C20
Liens externes :

Critères de population

Sexe : Homme et femme
Age minimum : 18 ans
Critères d’inclusion :
  1. Patient over 18 years old starting first-line treatment for metastatic colorectal cancer including BEVACIZUMAB (AVASTIN®)
  2. Systemic or intraocular anti-VEGF treatment naïve
  3. ECOG ≤ 2
Critères d’exclusion :
  1. Pregnant woman,
  2. Minor patient or under legal protection
  3. Person deprived of liberty or under guardianship
  4. Inability to undergo medical monitoring of the trial
  5. Impossibility of carrying out the OCT-A
  6. Patient with a contraindication to Tropicamide 0.5% eye drops
  7. Patient with a history of degenerative macular pathology, vascular macular pathology or presenting an epiretinal membrane with traction phenomenon.
  8. Diabetes
  9. Patient for whom it is not possible to schedule an ophthalmology consultation before the start of treatment.

Centre d'investigation

En cours
Nom : Centre Georges François Leclerc - CGFL
Ville : DIJON (21)
RESPONSABLE MÉDICAL
Nom : Pr LADOIRE
Prénom : Sylvain
Téléphone : Non disponible
Email : sladoire@cgfl.fr
CONTACT TECHNIQUE
Nom : SCHOUTITH
Prénom : Céline
Téléphone : 03 80 73 77 51
Email : cschoutith@cgfl.fr

Référentiels Oncologik

  • Rectum